Experimental model of ovarian cancer shows effect of healthy cell arrangement in metastasis

A key element to slowing metastasis in ovarian cancer is understanding the mechanisms of how tumor cells invade tissues. Biophysics researchers explain how microscopic defects in how healthy cells line up can alter how easily ovarian cancer cells invade tissue. Using an experimental model, the group found that disruptions in the normal cellular layout, called topological defects, affect the rate of tumor cell invasion.

Quelle: Sciencedaily

Researchers discover key stem cell dormancy mechanism which could help unlock future cancer treatments

Researchers have made new findings which provide a broader understanding of how dormant hematopoietic stem cells are activated and could pave the way towards therapeutic treatments for a number of cancers.

Quelle: Sciencedaily

Novel therapy shows promise for lung cancer patients with rare EGFR mutation

Researchers report on a multinational, early phase clinical trial evaluating a new targeted therapy for patients with metastatic or unresectable non-small cell lung cancer who have a specific genetic mutation: EGFR Ex20Ins.

Quelle: Sciencedaily

Statins may improve survival for triple-negative breast cancer patients

A new study found a significant association between cholesterol-lowering drugs commonly known as statins and survival rates of triple-negative breast cancer patients. Since statins are low in cost, easy to access and produce minimal side effects, this could have an important impact on outcomes for this aggressive disease.

Quelle: Sciencedaily

New treatment option for advanced urothelial cancer patients shows promise in a phase 2 clinical trial

A new treatment for advanced urothelial cancer was effective with tolerable side effects in an international, multi-center phase 2 clinical trial. The trial results prompted a U.S. Food and Drug Administration (FDA) accelerated approval of the treatment on April 13, giving patients with this very aggressive type of cancer a new therapeutic option.

Quelle: Sciencedaily

Atomic-level, 3-D structure of MUTYH protein opens small window into DNA repair mechanism

A research team has analyzed the three-dimensional structure of a protein that suppresses the development of colorectal polyposis, MUTYH, at the atomic level and clarified the repair mechanism for DNA mispairings. Since mutations in the MUTYH gene cause heritable colorectal polyposis, which leads to colorectal cancer, the researchers expect that this work will be useful for future research on heritable colorectal polyposis associated with MUTYH.

Quelle: Sciencedaily

Radio-wave therapy is safe for liver cancer patients and shows improvement in overall survival, study suggests

Researchers have shown that a targeted therapy using non-thermal radio waves is safe to use in the treatment of hepatocellular carcinoma (HCC), the most common type of liver cancer, according to a new study. The therapy also showed a benefit in overall survival.

Quelle: Sciencedaily

Source of DNA mutations in melanoma

The mutations that give rise to melanoma result from a chemical conversion in DNA fueled by sunlight — not just a DNA copying error as previously believed, reports a new study. The findings upend long-held beliefs about the mechanisms underlying the disease, reinforce the importance of prevention efforts and offer a path forward for investigating the origins of other cancer types.

Quelle: Sciencedaily

Crucial new molecular mechanisms and biomarkers in ovarian cancer

Medical researchers have discovered what appears to be an Achilles’ heel in ovarian cancers, as well as new biomarkers that could point to which patients are the best candidates for possible new treatments.

Quelle: Sciencedaily

New relevant target for PARP inhibitor talazoparib

Researchers report the identification of a new target for the PARP inhibitor drug talazoparib and show that combination treatment with talazoparib and the WEE1 inhibitor adavosertib results in enhanced anti-cancer effects.

Quelle: Sciencedaily

More genetic markers for inherited testicular cancer identified

A meta-analysis of nearly 200,000 men revealed 22 new genetic locations that could be susceptible to inherited testicular germ cell tumors.

Quelle: Sciencedaily

Eliminating RNA-binding protein improves survival in aggressive leukemia

Removing a protein that is often overexpressed in a rare and aggressive subtype of leukemia can help to slow the cancer’s development and significantly increase the likelihood of survival, according to a new study in mice.

Quelle: Sciencedaily

Studies uncover details of ‘exhausted’ immune cells in patients with chronic infections

Two new studies provide insights into T cell exhaustion, which could lead to potential strategies to overcome it.

Quelle: Sciencedaily

Scientists advance breast, ovarian cancer research with cryo-electron microscopy

Using advanced imaging technology, scientists have provided an unprecedented understanding of the BRCA1-BARD1 protein complex, which is often mutated in patients with breast or ovarian cancer. Their paper identifies aspects of how BRCA1-BARD1 functions, supporting future translational research, cancer prevention efforts and drug development.

Quelle: Sciencedaily

Seeking a unique treatment for lobular breast cancer

In an attempt to find out why the long-term outcomes are poorer for patients with lobular breast cancer — which affects some 40,000 women a year — researchers began looking at the role of the protein MDC1 in tumor cells.

Quelle: Sciencedaily

Healthy lifestyle may help mitigate high genetic risk of cancer

Healthy lifestyle factors such as abstinence from smoking and drinking, low body mass index, and exercise correlated with decreased cancer incidence, even in individuals with a high genetic risk.

Quelle: Sciencedaily

Discovery within human cell cycle process to bring new understanding of cellular diseases

New research has uncovered an essential mechanism coordinating the processes of cell division and adhesion within humans. This discovery has profound potential for advancing understanding of cell adhesion signalling in cancerous tumor progression and metastasis.

Quelle: Sciencedaily

Black American women with vitamin D insufficiency more likely to test positive for COVID-19, study finds

In a recent study of Black American women, low levels of vitamin D appeared to be related to increased incidence of COVID-19 infection.

Quelle: Sciencedaily

New approach for cell therapy shows potential against solid tumors with KRAS mutations

A new technology for cellular immunotherapy showed promising anti-tumor activity in the lab against hard-to-treat cancers driven by the once-considered “undruggable” KRAS mutation, including lung, colorectal, and pancreatic.

Quelle: Sciencedaily

DNA tags enable blood-based tests to assess cancer treatment outcomes

Cell-free DNA (cfDNA) shed into the blood was discovered in the late 1940s but with rapid advances in genomics and computational analytics in just the past few years, researchers now believe that studying tags, or modifications to this type of DNA, may lead to a better understanding of how to assess, and possibly modulate, treatment approaches for cancer and other diseases.

Quelle: Sciencedaily

New breakthrough to help immune systems in the fight against cancer

New research has identified potential treatment that could improve the human immune system’s ability to search out and destroy cancer cells within the body. Scientists have identified a way to restrict the activity of a group of cells which regulate the immune system, which in turn can unleash other immune cells to attack tumours in cancer patients.

Quelle: Sciencedaily

Comprehensive clinical sequencing opens door to the promise of precision medicine

A new study highlights the power of comprehensive whole genome, whole exome and RNA sequencing to better understand and treat each patient’s cancer.

Quelle: Sciencedaily

New organ-on-a-chip finds crucial interaction between blood, ovarian cancer tumors

Researchers are pushing organ-on-a-chip devices to new levels that could change the way clinicians approach cancer treatment, particularly ovarian cancer.

Quelle: Sciencedaily

New understanding of cell stability with potential to improve immune cell therapies

Researchers have developed two solutions with potential to overcome a key clinical limitation of immune cell therapies.

Quelle: Sciencedaily

Potential role of ‘junk DNA’ sequence in aging, cancer

Researchers have recently identified a DNA region known as VNTR2-1 that appears to drive the activity of the telomerase gene, which has been shown to prevent aging in certain types of cells. Knowing how the telomerase gene is regulated and activated and why it is only active in certain cell types could someday be the key to understanding how humans age and how to stop the spread of cancer.

Quelle: Sciencedaily