Guidance on supplemental breast cancer screening for women with dense breast tissue

Researchers have made recommendations for clinicians and patients regarding supplemental screening for women with dense breast tissue.

Quelle: Sciencedaily

Starting mammography at age 40 would reduce disparities in deaths for Black women

If Black women begin mammography screening every other year starting at age 40, breast cancer deaths could be reduced by 57 percent compared to starting screening 10 years later according to recent analyses.

Quelle: Sciencedaily

Prediction models may reduce false-positives in MRI breast cancer screening

Prediction models based on clinical characteristics and imaging findings may help reduce the false-positive rate in women with dense breasts who undergo supplemental breast cancer screening with MRI, according to a new study.

Quelle: Sciencedaily

Researchers solve structure of BRCA2 protein complex important in DNA repair

The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA. The breakdown of this interaction is a hallmark of many cancers. Now scientists have determined the structure of a complex of two proteins — BRCA2 together with MEILB2 — that allows repairs to happen efficiently in cells undergoing cell-splitting, called meiosis. Their results have major implications for cancer and infertility.

Quelle: Sciencedaily

Changes in lung tissue indicate preparation for supporting the growth of disseminated breast cancer cells

A new study has revealed changes in healthy lung tissue which indicate preparation to receive metastases. The changes were identified in the area known as ‚the micro-environment‘ of the tumor, and specifically in connective tissue known as fibroblasts.

Quelle: Sciencedaily

Statins may improve survival for triple-negative breast cancer patients

A new study found a significant association between cholesterol-lowering drugs commonly known as statins and survival rates of triple-negative breast cancer patients. Since statins are low in cost, easy to access and produce minimal side effects, this could have an important impact on outcomes for this aggressive disease.

Quelle: Sciencedaily

Seeking a unique treatment for lobular breast cancer

In an attempt to find out why the long-term outcomes are poorer for patients with lobular breast cancer — which affects some 40,000 women a year — researchers began looking at the role of the protein MDC1 in tumor cells.

Quelle: Sciencedaily

Maternal diets rich in Omega-3 fatty acids may protect offspring from breast cancer, study suggests

Researchers noted a significant difference in mice from mothers that were fed a diet rich in canola oil, compared with mothers fed a diet rich in corn oil. A maternal Omega 3-rich diet affected genome-wide epigenetic landscape changes in offspring and potentially modulated gene expression patterns.

Quelle: Sciencedaily

Cholesterol metabolite induces production of cancer-promoting vesicles

Scientists studying the link between cholesterol and breast cancer report that a byproduct of cholesterol metabolism causes some cells to send out cancer-promoting signals to other cells. These signals are packaged in membrane-bound compartments called extracellular vesicles.

Quelle: Sciencedaily

New findings offer improved therapy of early-stage, BRCA mutation-associated breast cancer

A new treatment has potential to improve the outcomes for patients with hereditary BRCA mutations and high-risk, early-stage breast cancer. These results represent the first time a PARP inhibitor has been shown to significantly reduce the risk of breast cancer returning in high-risk patients following completion of standard chemotherapy, surgery and radiation therapy.

Quelle: Sciencedaily

The micro-environment of breast cancer in three dimensions

Cancerous tumors thrive on blood, extending their roots deep into the fabric of the tissue of their host. They alter the genetics of surrounding cells and evolve to avoid the protective attacks of immune cells. Now, researchers have developed a way to study the relationship between solid, difficult-to-treat tumors and the microenvironment they create to support their growth.

Quelle: Sciencedaily

Review summarizes known links between endocrine disruptors and breast cancer risk

Exposure to certain endocrine-disrupting chemicals could elevate the risk of breast cancer, according to a new comprehensive systematic review of epidemiological research. However, for many chemicals, evidence is inconsistent or still limited.

Quelle: Sciencedaily

A leap forward in research on CAR T cell therapy

A study looked into how CAR T immunotherapy could be used to treat solid tumors in addition to leukemias. The programming of CAR T cells opens avenues for applying cell therapies to, for example, breast cancer or ovarian cancer in the future.

Quelle: Sciencedaily

Exposure to common chemical during pregnancy may reduce protection against breast cancer

Low doses of propylparaben – a chemical preservative found in food, drugs and cosmetics – can alter pregnancy-related changes in the breast in ways that may lessen the protection against breast cancer that pregnancy hormones normally convey, according to new research.

Quelle: Sciencedaily

Breast cancer: The risks of brominated flame retardants

Brominated flame retardants may lead to early mammary gland development, which is linked to an increased risk of breast cancer.

Quelle: Sciencedaily

Making the role of AI in medicine explainable

Researchers have developed a new tissue-section analysis system for diagnosing breast cancer based on artificial intelligence (AI). For the first time, morphological, molecular and histological data are integrated in a single analysis. Furthermore, the system provides a clarification of the AI decision process in the form of heatmaps.

Quelle: Sciencedaily

What to do when a mammogram shows swollen lymph nodes in women just vaccinated for COVID

When women undergo breast imaging shortly after receiving a COVID-19 vaccine in the arm, their tests may show swollen lymph nodes in the armpit area. Radiologists say that this is usually a normal finding, and if there are no other concerns, no additional imaging tests are needed unless the lymph nodes remain swollen for more than six weeks after vaccination. The team has published an approach to help avoid delays in both vaccinations and breast cancer screening.

Quelle: Sciencedaily

Drug is promising against pancreatic and breast cancers

The drug is effective at treating pancreatic cancer and prolonging survival in mice, according to a new study. A second study shows the drug is also effective against triple-negative breast cancer, a fast-growing and hard-to-treat type of breast cancer that carries a poor prognosis. Clinical trials are set to begin in 2021.

Quelle: Sciencedaily

Halt cell recycling to treat cancer

Targeting and changing autophagy, otherwise known as cell recycling, has been linked to helping control or diminish certain cancers. Now, researchers have shown that completely halting this process in a very aggressive form of breast cancer may improve outcomes for patients one day.

Quelle: Sciencedaily

Popular breast cancer drugs don’t work the way we thought they did

New research suggests that a class of drugs called PARP inhibitors, designed to treat hereditary forms of ovarian and breast cancer, don’t work the way we thought they did. It also paints a fuller picture of how they work, opening the door to improvements in next-generation drugs.

Quelle: Sciencedaily

Imaging identifies breast cancer patients unlikely to benefit from hormone therapy

Hormone therapy can be very effective for so-called estrogen receptor-positive breast cancer. But it only works for a little more than half of women who receive the treatment. In a small study, researchers found that women whose tumors did not respond to a one-day estrogen challenge did not benefit from hormone therapy. The findings could help doctors choose treatments most likely to help their patients.

Quelle: Sciencedaily

New discovery in breast cancer treatment

Researchers have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease.

Quelle: Sciencedaily

Statins may protect the heart from chemotherapy treatment of early breast cancer

Women who take statins, the common cholesterol-lowering medication, during chemotherapy with anthracyclines for early-stage breast cancer are half as likely to require emergency department visits or hospitalization for heart failure in the 5 years after chemotherapy.

Quelle: Sciencedaily

Study points the way to boost immunotherapy against breast cancer, other solid tumors

Researchers report that adding a small molecule to a chimeric antigen receptor-T (CAR-T) cell therapy can help immune system T cells to effectively attack solid tumors, such as breast cancers. The boost helps recruit more immune cells into battle at the tumor site, according to the new study.

Quelle: Sciencedaily

Surgery may offer survival advantage in certain metastatic breast cancers

Surgery, in addition to treatments like chemotherapy and radiation therapy, may increase the length of survival for metastatic breast cancer patients, according to researchers.

Quelle: Sciencedaily