Sugar-sweetened drinks linked to increased risk of colorectal cancer in women under 50, study finds

Colorectal cancer diagnoses have increased among people under age 50 in recent years and researchers are seeking reasons why. A new study has found a link between drinking sugar-sweetened beverages and an increased risk of developing colorectal cancer in women under age 50. The findings suggest that heavy consumption of sugary drinks during adolescence (ages 13 to 18) and adulthood can increase the disease risk.

Quelle: Sciencedaily

Process for eliminating unneeded cells may also protect against cancer

Biologists find cell extrusion, a process that helps organisms eliminated unneeded cells, is triggered when cells can’t replicate their DNA during cell division. In humans, extrusion may serve as a way for the body to eliminate cancerous or precancerous cells.

Quelle: Sciencedaily

Restricting growth, spread of head and neck cancers

Researchers have discovered a key molecule that allows cancer stem cells to bypass the body’s natural immune defenses, spurring the growth and spread of head and neck squamous cell cancers. Their study, conducted in mice, also demonstrates that inhibiting this molecule derails cancer progression and helps eliminate these stem cells.

Quelle: Sciencedaily

3D ‘bioprinting’ used to create nose cartilage

A team of University of Alberta researchers has discovered a way to use 3-D bioprinting technology to create custom-shaped cartilage for use in surgical procedures. The work aims to make it easier for surgeons to safely restore the features of skin cancer patients living with nasal cartilage defects after surgery.

Quelle: Sciencedaily

The micro-environment of breast cancer in three dimensions

Cancerous tumors thrive on blood, extending their roots deep into the fabric of the tissue of their host. They alter the genetics of surrounding cells and evolve to avoid the protective attacks of immune cells. Now, researchers have developed a way to study the relationship between solid, difficult-to-treat tumors and the microenvironment they create to support their growth.

Quelle: Sciencedaily

Engineering T cells to attack cancer broadly

This study builds on decades of work showing that the protein IL-24 attacks cancer broadly, and is the first to deliver the protein using T cells. This approach is in contrast to CAR-T cells, which are built to recognize proteins on the surface of cancer cells and haven’t been successful against solid tumors. Mice with prostate cancer experienced shrinkage of the original tumor as well as distant metastases following treatment with IL-24 T cells.

Quelle: Sciencedaily

New genetic target for blood cancer treatment

Researchers have identified a vulnerability in some cases of acute myeloid leukaemia that could be harnessed for targeted treatment of these poor-prognosis cancers.

Quelle: Sciencedaily

Single-cell CRISPR technology deciphers role of chromatin accessibility in cancer

Researchers have developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide. The new method harnesses the programmability of the gene editing system CRISPR to knock-out nearly all chromatin-related genes in parallel, offering researchers deeper insights into the role of DNA accessibility in cancer and in rare diseases involving chromatin.

Quelle: Sciencedaily

How oxygen radicals protect against cancer

Oxygen radicals in the body are generally considered dangerous because they can trigger something called oxidative stress, which is associated with the development of many chronic diseases such as cancer and cardiovascular disease. In studies on mice, scientists have now discovered how oxygen radicals, conversely, can also reduce the risk of cancer and mitigate damage to the hereditary molecule DNA.

Quelle: Sciencedaily

Men’s loneliness linked to an increased risk of cancer

A recent study shows that loneliness among middle-aged men is associated with an increased risk of cancer.

Quelle: Sciencedaily

Force transmission between cells orchestrates collective cellular motion

How do the billions of cells communicate in order to perform tasks? The cells exert force on their environment through movement – and in doing so, they communicate. They work as a group in order to infiltrate their environment, perform wound healing and the like. They sense the stiffness or softness of their surroundings and this helps them connect and organize their collective effort. But when the connection between cells is distrubeddisturbed, a situation just like when cancer is initiated, can appear.

Quelle: Sciencedaily

Genetic effects of Chernobyl radiation

Researchers utilized genomic tools to investigate potential health effects of exposure to ionizing radiation, a known carcinogen, as a result of the 1986 Chernobyl accident. One study found no evidence that genetic changes associated with radiation exposure are passed to children, while the second study documented the genetic changes in the tumors of people who developed thyroid cancer after being exposed as children or fetuses to the radiation released by the accident. Findings are being published close to the 35th anniversary of the Chernobyl disaster.

Quelle: Sciencedaily

Artificial intelligence model predicts which key of the immune system opens the locks of coronavirus

A new artificial intelligence (AI) method is helping researchers link immune cells to their targets and, for example, uncouple which white blood cells recognize SARS-CoV-2. The tool has broad applications in understanding the function of the immune system in infections, autoimmune disorders, and cancer.

Quelle: Sciencedaily

Average-risk individuals may prefer stool-based test over colonoscopy for cancer screening

When given a choice, most individuals with an average risk of colorectal cancer said they would prefer a stool-based screening test for colorectal cancer over colonoscopy, the method most often recommended by health care providers.

Quelle: Sciencedaily

Higher mushroom consumption is associated with a lower risk of cancer

Higher mushroom consumption is associated with a lower risk of cancer, according to a new study. The systematic review and meta-analysis examined 17 cancer studies published from 1966 to 2020. Analyzing data from more than 19,500 cancer patients, researchers explored the relationship between mushroom consumption and cancer risk.

Quelle: Sciencedaily

‘Undruggable’ cancer protein becomes druggable, thanks to shrub

A chemist has found a way to synthesize a compound to fight a previously ‘undruggable’ cancer protein with benefits across a myriad of cancer types.

Quelle: Sciencedaily

‘Information theory’ recruited to help scientists find cancer genes

Using a widely known field of mathematics designed mainly to study how digital and other forms of information are measured, stored and shared, scientists say they have uncovered a likely key genetic culprit in the development of acute lymphoblastic leukemia (ALL).

Quelle: Sciencedaily

Review summarizes known links between endocrine disruptors and breast cancer risk

Exposure to certain endocrine-disrupting chemicals could elevate the risk of breast cancer, according to a new comprehensive systematic review of epidemiological research. However, for many chemicals, evidence is inconsistent or still limited.

Quelle: Sciencedaily

Europaflagge über 73. Urologen-Kongress – DGU-Präsident Stenzl forciert internationale Zusammenarbeit in der Urologie

Während die einen den Brexit vollziehen, steht mit Prof. Dr. Dr. h.c. Arnulf Stenzl ein überzeugter Europäer an der Spitze der deutschen Urologie. Der amtierende Präsident der Deutschen Gesellschaft für Urologie e.V. (DGU) hat sich seit Jahren der internationalen Zusammenarbeit in der Urologie verschrieben, ist, neben seinem Engagement in der deutschen Fachgesellschaft, Adjunct Secretary Science der European Association of Urology (EAU) und Mitglied des Leitungsgremiums der European Cancer Organisation (ECO).

Quelle: IDW Informationsdienst Wissenschaft

Innovative technique developed to destroy cancerous kidney cells

An innovative new technique that encourages cancer cells in the kidneys to self-destruct could revolutionize the treatment of the disease.

Quelle: Sciencedaily

Study reveals cancer immunotherapy patients at most risk of life-threatening side effects

Immune checkpoint inhibitors boost a patient’s immune response against cancer cells, but they can cause potentially life-threatening side effects in some individuals. New research may help clinicians determine which patients are most at risk.

Quelle: Sciencedaily

Common drug could be used to prevent certain skin cancers

New data suggests that an oral drug currently used in the clinical setting to treat neuromuscular diseases could also help prevent a common form of skin cancer caused by damage from ultraviolet-B radiation from the sun.

Quelle: Sciencedaily

165 new cancer genes identified with the help of machine learning

A new algorithm can predict which genes cause cancer, even if their DNA sequence is not changed. A team of researchers combined a wide variety of data, analyzed it with ‘Artificial Intelligence’ and identified numerous cancer genes. This opens up new perspectives for targeted cancer therapy in personalized medicine and for the development of biomarkers.

Quelle: Sciencedaily

Study reveals crucial details on skin-related side effects of cancer immune therapies

Immune checkpoint inhibitors are life-saving therapies against advanced cancer, but they can cause side effects, most commonly involving the skin. New research provides insights on the extent of these side effects, when they tend to arise, and which patients may be most at risk of experiencing them.

Quelle: Sciencedaily

A tummy invader: This bacterial molecule may be key to fighting stomach cancer

Researchers found that H. pylori bacterial strains with low expression of a small RNA molecule called HPnc4160 are more likely to adapt to living in the human stomach. Gastric cancer patients have lower levels of HPnc4160, as well as higher levels of pathogenic bacterial proteins, than individuals without cancer. This work provides crucial knowledge for the development of new treatments for chronic H. pylori infections and gastric cancer.

Quelle: Sciencedaily