Microglia, Stockholm syndrome and miraculous cures in glioblastoma patients

University of Minnesota Medical School researchers revealed why some glioblastoma patients see exceptional benefits from chemotherapy and survive beyond expectations.

Quelle: Sciencedaily

Chemo for glioblastoma may work better in morning than evening

An aggressive type of brain cancer, glioblastoma has no cure. Patients survive an average of 15 months after diagnosis, with fewer than 10% of patients surviving longer than five years. While researchers are investigating potential new therapies via ongoing clinical trials, a new study suggests that a minor adjustment to the current standard treatment — giving chemotherapy in the morning rather than the evening — could add a few months to patients’ survival.

Quelle: Sciencedaily

Double trouble for drug-resistant cancers

New research identifies chemotherapy-resistant cancers’ escape mechanism, which offers new anti-cancer treatment options.

Quelle: Sciencedaily

Cancer cells may evade chemotherapy by going dormant

Cancer cells can dodge chemotherapy by entering a state that bears similarity to certain kinds of senescence, a type of ‘active hibernation’ that enables them to weather the stress induced by aggressive treatments aimed at destroying them, according to a new study. These findings have implications for developing new drug combinations that could block senescence and make chemotherapy more effective.

Quelle: Sciencedaily

Therapy sneaks into hard layer of pancreatic cancer tumor and destroys it from within

Researchers demonstrated that a new tumor-penetrating therapy could enhance the effects of chemotherapy, reduce the spread of pancreatic cancer and increase survival in animal models.

Quelle: Sciencedaily

New inhibitor found to combat drug-resistant cancer cells

A new substance could improve the treatment of persistent cancers. Researchers have developed a new inhibitor that makes drug-resistant tumor cells respond again to chemotherapy. The new substance blocks a protein in the cancer cells that normally transports the cancer drugs back out of the cells.

Quelle: Sciencedaily

Single cell sequencing opens new avenues for eradicating leukemia at its source

Cancer stem cells that elude conventional treatments like chemotherapy drive long-term cancer growth and relapse. These cells are difficult to isolate and study because of their low abundance and similarity to other stem cells. Researchers have created a new method that can distinguish cancer stem cells, mature cancer cells and otherwise healthy stem cells based on their genetics and gene expression. The findings open new avenues for cancer research personalised medicine.

Quelle: Sciencedaily

Ionic liquid uniformly delivers chemotherapy to tumors while destroying cancerous tissue

Vascular and interventional radiologists report the development of a new ionic liquid formulation that killed cancer cells and allowed uniform distribution of a chemotherapy drug into liver tumors and other solid tumors in the lab. This discovery could solve a problem that has long plagued drug delivery to tumors.

Quelle: Sciencedaily

Finding a way to stop chemotherapy from damaging the heart

There could be an intervention on the horizon to help prevent heart damage caused by the common chemotherapy drug doxorubicin, new research suggests.

Quelle: Sciencedaily

New maintenance treatment for acute myeloid leukemia prolongs the lives of patients

Patients with acute myeloid leukemia (AML), the most common form of acute leukemia in adults, that has gone into remission following initial chemotherapy remain in remission longer and have improved overall survival when they are given a pill form of the cancer drug azacitidine as a maintenance treatment, according to a randomized, international phase 3 clinical trial.

Quelle: Sciencedaily

Cancer cells hibernate like bears to evade harsh chemotherapy

Researchers show that cancer cells hijack an evolutionary conserved program to survive chemotherapy. Furthermore, the researchers show that novel therapeutic strategies aimed at specifically targeting cancer cells in this slow-dividing state can prevent cancer regrowth.

Quelle: Sciencedaily

Statins may protect the heart from chemotherapy treatment of early breast cancer

Women who take statins, the common cholesterol-lowering medication, during chemotherapy with anthracyclines for early-stage breast cancer are half as likely to require emergency department visits or hospitalization for heart failure in the 5 years after chemotherapy.

Quelle: Sciencedaily

Heat treatment may make chemotherapy more effective

The study found that ‘loading’ a chemotherapy drug on to tiny magnetic particles that can heat up the cancer cells at the same time as delivering the drug to them was up to 34% more effective at destroying the cancer cells than the chemotherapy drug without added heat.

Quelle: Sciencedaily

Surgery may offer survival advantage in certain metastatic breast cancers

Surgery, in addition to treatments like chemotherapy and radiation therapy, may increase the length of survival for metastatic breast cancer patients, according to researchers.

Quelle: Sciencedaily

Potential cancer therapy may boost immune response

A new approach to cancer therapy shows potential to transform the commonly used chemotherapy drug gemcitabine into a drug that kills cancer cells in a specialized way, activating immune cells to fight the cancer.

Quelle: Sciencedaily

A DNA-based nanogel for targeted chemotherapy

Current chemotherapy regimens slow cancer progression and save lives, but these powerful drugs affect both healthy and cancerous cells. Now, researchers have designed DNA-based nanogels that only break down and release their chemotherapeutic contents within cancer cells, minimizing the impacts on normal ones and potentially eliminating painful and uncomfortable side effects.

Quelle: Sciencedaily

Predicting the risk of severe side effects of cancer treatment

The risk of serious adverse effects on the blood status and bone marrow of patients during chemotherapy can be predicted by a new model. This research may make it possible to use genetic analysis to identify patients with a high probability of side effects.

Quelle: Sciencedaily

Calcium bursts kill drug-resistant tumor cells

Multidrug resistance (MDR) — a process in which tumors become resistant to multiple medicines — is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that pump drugs out of the cell, rendering the chemotherapies ineffective. Now, researchers have developed nanoparticles that release bursts of calcium inside tumor cells, inhibiting drug pumps and reversing MDR.

Quelle: Sciencedaily

Researchers make counterintuitive discoveries about immune-like characteristics of cells

Biologists reveal that tissue perturbations by chemotherapy agents promote stem cell expansion and that fibroblast cells exhibit unexpected, immune-like behavior.

Quelle: Sciencedaily

Experimental glioblastoma therapy shows curative powers in mice models

Researchers used a second-generation pro-drug called MP-Pt(IV) to target the deadly cells of glioblastoma tumors and found mice harboring human glioblastoma tumors in their brains had greatly enhanced survival and weight gain when given the newly developed prodrug. This mitochondrial-targeted prodrug also greatly improves outcomes when coupled with standard therapies of radiation and/or chemotherapy.

Quelle: Sciencedaily

Keys to control the ‘driver of cancer’s aggressiveness’

A dangerous protein named SNAI2 helps cancers metastasize and shields cancer from both the immune system and chemotherapy. Worse, SNAI2 is in a family of proteins that are notoriously hard to fight with drugs. But now researchers have found a way to use the cell’s recycling system to control SNAI2, providing a new possibility for treatments.

Quelle: Sciencedaily

Cancer: Dismantling the web of death

Cancer is one of the most frequent causes of death. Chemotherapy is often used as a treatment, but also brings side effects for healthy organs. Scientists are now trying to take a completely different approach: By means of targeted and localized disruption of the cancer cells’ structure, its self-destruction mechanism can be activated. In laboratory experiments, they have already demonstrated initial successes.

Quelle: Sciencedaily

Single-cell RNA sequencing sheds new light on cancer cells’ varied response to chemotherapy

Single-cell analysis, done in three colon cancer cell lines, is believed to be the first to profile transcriptome-level changes in response to DNA damage across individual cells.

Quelle: Sciencedaily

Cancer and its treatment may accelerate the aging process in young patients

A new study examines the effects of cancer and its treatment on the aging process. Investigators found that expression of a gene associated with aging is higher in young patients with cancer after treatment with chemotherapy and in young cancer survivors who are frail.

Quelle: Sciencedaily

New nano drug candidate kills aggressive breast cancer cells

Researchers have developed a new drug candidate that kills triple negative breast cancer cells. The discovery will help clinicians target breast cancer cells directly, while avoiding the adverse, toxic side effects of chemotherapy.

Quelle: Sciencedaily