Discovery within human cell cycle process to bring new understanding of cellular diseases

New research has uncovered an essential mechanism coordinating the processes of cell division and adhesion within humans. This discovery has profound potential for advancing understanding of cell adhesion signalling in cancerous tumor progression and metastasis.

Quelle: Sciencedaily

New breakthrough to help immune systems in the fight against cancer

New research has identified potential treatment that could improve the human immune system’s ability to search out and destroy cancer cells within the body. Scientists have identified a way to restrict the activity of a group of cells which regulate the immune system, which in turn can unleash other immune cells to attack tumours in cancer patients.

Quelle: Sciencedaily

Investigational magnetic device shrinks glioblastoma in human test

Researchers shrunk a deadly glioblastoma tumor by more than a third using a helmet generating a noninvasive oscillating magnetic field that the patient wore on his head while administering the therapy in his own home. The 53-year-old patient died from an unrelated injury about a month into the treatment, but during that short time, 31% of the tumor mass disappeared. The autopsy of his brain confirmed the rapid response to the treatment.

Quelle: Sciencedaily

Why identical mutations cause different types of cancer

Why do alterations of certain genes cause cancer only in specific organs of the human body? Scientists have now demonstrated that cells originating from different organs are differentially susceptible to activating mutations in cancer drivers.

Quelle: Sciencedaily

Pathogenic fungi colonise microplastics in soils

Representatives of numerous pathogenic fungal species are finding new habitat on microplastic particles in the soil and could thus be one of the possible causes of an increase in fungal infections. Researchers from Bayreuth, Hannover and Munich demonstrated this in a new study. Using high-throughput methods, the scientists analysed fungal communities from soil samples taken from sites near human settlements in western Kenya. The findings of this research have been published in the journal Scientific Reports.

Quelle: IDW Informationsdienst Wissenschaft

COR-101 is Inhibiting the Emerging “Indian” Variants of SARS-CoV-2 including “Delta”

The human recombinant anti-SARS-CoV-2 antibody COR-101 was developed in close cooperation of Technische Universität Braunschweig, the Helmholtz Centre for Infection Research (HZI) and the biotech company YUMAB GmbH in Braunschweig. The antibody is currently undergoing phase Ib/II clinical trials for the treatment of moderate to severe COVID-19 by CORAT Therapeutics GmbH. The story of the discovery and development of this antibody was now published in the Journal “Cell Reports”.

Quelle: IDW Informationsdienst Wissenschaft

Taking the brain out for a walk

A recent study shows that spending time outdoors has a positive effect on our brains.
If you’re regularly out in the fresh air, you’re doing something good for both your brain and your well-being. This is the conclusion reached by researchers at the Max Planck Institute for Human Development and the Medical Center Hamburg-Eppendorf (UKE). The longitudinal study recently appeared in The World Journal of Biological Psychiatry.

Quelle: IDW Informationsdienst Wissenschaft

Mechanical stimuli influence organ growth – complex interactions of cells and tissue

In addition to chemical factors, mechanical influences play an important role in the natural growth of human organs such as kidneys, lungs and mammary glands – but also in the development of tumors. Now a research team at the Technical University of Munich (TUM) has investigated the process in detail using organoids, three-dimensional model systems of such organs which are produced in the laboratory.

Quelle: IDW Informationsdienst Wissenschaft

Development of the World’s First Digital Model of a Cancer Cell

The computer model, developed under the lead management of researchers at TU Graz, simulates the cyclical changes in the membrane potential of a cancer cell using the example of human lung adenocarcinoma and opens up completely new avenues in cancer research.

Quelle: IDW Informationsdienst Wissenschaft

Leopard gecko skin tumors traced to cancer gene

In a rare gecko color variety known as Lemon Frost, scientists have traced an unusual coloring and tendency to form tumors to a gene linked to human melanoma.

Quelle: Sciencedaily

Nature article: Researchers detect inflamed brain cells in patients with severe COVID

Many patients who have survived a severe COVID-19 infection suffer from neurological abnormalities, such as impaired speech, memory loss or depression. So far little is known about what impact the coronavirus has on the human brain. A team of researchers from Saarland University and Stanford University has discovered that in patients with severe COVID-19, the SARS-CoV-2 virus can activate immune and barrier cells in the brain. The gene expression patterns found by the research team exhibit features similar to those found in individuals with cognitive disorders, schizophrenia and depression. The study has now been published in the world-renowned science journal ‘Nature’.

Quelle: IDW Informationsdienst Wissenschaft

Most cancer cells grown in a dish have little in common with cancer cells in people, research finds

In a bid to find or refine laboratory research models for cancer that better compare with what happens in living people, scientists report they have developed a new computer-based technique showing that human cancer cells grown in culture dishes are the least genetically similar to their human sources.

Quelle: Sciencedaily

Novel molecular mechanism contributing to the pathogenesis of IPF: human microRNA-506-Quaking axis as a master switch

A team of scientists of the Fraunhofer ITEM, the Hannover Medical School and FAU Erlangen-Nürnberg has discovered a novel molecular regulatory axis that plays a decisive role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The focus is on the RNA-binding protein Quaking and its functional interplay with microRNAs. In-silico as well as in-vitro experiments in human lung fibroblasts revealed a novel regulatory microRNA-506-Quaking axis that contributes to IPF pathogenesis. The study has been published in Nature’s Scientific Reports. These findings open up new options for IPF therapies, for example based on RNA therapeutics or small molecules.

Quelle: IDW Informationsdienst Wissenschaft

Piecing together the full picture of the genome

A team of international researchers from the Friedrich Miescher Laboratory of the Max Planck Society developed a new DNA sequencing method that provides fast and efficient tracking of genetic information. Their new technique called haplotagging now enables scientists to quickly and precisely trace and match genome data. Haplotagging delivers rich genome information and facilitates accurate determination of our genetic make-up. This allows for fast genetic analyses in human populations or reveals previously unsuspected mixing of species in nature. The results now appear in PNAS and in Nature Genetics.

Quelle: IDW Informationsdienst Wissenschaft

New discovery shows human cells can write RNA sequences into DNA

In a discovery that challenges long-held dogma in biology, researchers show that mammalian cells can convert RNA sequences back into DNA, a feat more common in viruses than eukaryotic cells.

Quelle: Sciencedaily

One for all: Convergent mechanism of ageing discovered

Researchers at the Max Planck Institute for Biology of Ageing and the Cluster of Excellence for Ageing Research CECAD at the University of Cologne have discovered folate metabolism as a fundamental process for ageing. Its regulation underlies many known ageing signaling pathways and leads to longevity. This could provide a new opportunity to improve human health during ageing on a broad basis.

Quelle: IDW Informationsdienst Wissenschaft

Juvenile white-tailed sea eagles stay longer in their parental territory than nest protection periods

The white-tailed sea eagle is known for reacting sensitively to human disturbances. Forestry and agricultural activities are therefore restricted in the immediate vicinity of the nests. However, these seasonal protection periods are too short in the German federal States of Brandenburg (until August 31) and Mecklenburg-Western Pomerania (until July 31), as a new scientific analysis by a team of scientists from the Leibniz-IZW suggests. Using detailed movement data of 24 juvenile white-tailed sea eagles with GPS transmitters, they were able to track when they fledge and when they leave the parental territory: on average, a good 10 and 23 weeks after hatching, respectively.

Quelle: IDW Informationsdienst Wissenschaft

Infection with human papillomavirus linked to higher risk of preterm birth

Women carrying human papillomavirus (HPV) run an elevated risk of preterm birth, a new study shows. A connection can thus be seen between the virus itself and the risk for preterm birth that previously has been observed in pregnant women who have undergone treatment for abnormal cell changes due to HPV.

Quelle: Sciencedaily

Face to face

The human brain remembers faces better after a personal meeting than by looking at photos or videos, according to findings by neuroscientists at Friedrich Schiller University Jena. In the current issue of the “Journal of Neuroscience”, the research team led by Prof. Gyula Kovács and Dr Géza Gergely Ambrus have published EEG data which show that the familiarity of a face is anchored measurably more strongly in the brain of the observer if the face is seen in person.

Quelle: IDW Informationsdienst Wissenschaft

Researchers seek deeper understanding on how cells in the body operate

Cells sense and respond to the mechanical properties of the cellular microenvironment in the body. Changes in these properties, which occur in a number of human pathologies, including cancer, can elicit abnormal responses from cells. How the cells adapt to such changes in the mechanical microenvironment is not well understood.

Quelle: Sciencedaily

Can antibiotics treat human diseases in addition to bacterial infections?

A new study shows that eukaryotic ribosomes can be modified to respond to antibiotics in the same way that prokaryotic ribosomes do.

Quelle: Sciencedaily

New miniature organ to understand human pancreas development

Dresden and Copenhagen researchers establish human pancreas culture system.

Quelle: IDW Informationsdienst Wissenschaft

Major advance enables study of genetic mutations in any tissue

For the first time, scientists are able to study changes in the DNA of any human tissue, following the resolution of long-standing technical challenges. The new method, called nanorate sequencing (NanoSeq), makes it possible to study how genetic changes occur in human tissues with unprecedented accuracy.

Quelle: Sciencedaily

Chickens and pigs with integrated genetic scissors

Genetically engineered animals provide important insights into the molecular basis of health and disease. Research has focused mainly on genetically modified mice, although other species, such as pigs, are more similar to human physiology. Researchers have now generated chickens and pigs in which target genes in desired organs can be efficiently altered.

Quelle: Sciencedaily

How SARS-Coronaviruses reprogram the human cell to their own benefit

Coronavirus researchers under Prof. Rolf Hilgenfeld of the University of Lübeck and Dr. Albrecht von Brunn of the Ludwig-Maximilians University of Munich published a research breakthrough in the highly ranked “EMBO Journal”. They discovered how SARS viruses enhance the production of viral proteins in infected cells, so that many new copies of the virus can be generated. Other coronaviruses apart from SARS-CoV and SARS-CoV-2 do not use this mechanism, thereby providing a possible explanation for the much higher pathogenicity of the SARS viruses.

Quelle: IDW Informationsdienst Wissenschaft