Immune system-stimulating nanoparticle could lead to more powerful vaccines

Researchers designed a new nanoparticle adjuvant that may be more potent than others now in use. Studies in mice showed it significantly improved antibody production following vaccination against HIV, diphtheria and influenza.

Quelle: Sciencedaily

Harnessing the organization of the cell surface

Scientists have developed a new method to determine how proteins are organized on the surface of cells. Insights gained with the technology could lead to the development of novel drugs to fight cancer.

Quelle: Sciencedaily

Scientists pinpoint protein’s role in critical gene expression

New research has implications for cancer research because it explains part of the paradox for how cells can transcribe genes in the absence of high-energy sources, a situation that unfolds in cancer and has puzzled researchers for years.

Quelle: Sciencedaily

Magnetic resonance imaging (MRI) and artificial intelligence (AI) can detect early signs of tumor cell death after novel therapy

A recent study demonstrates that magnetic resonance imaging (MRI) and artificial intelligence (AI) can be used to detect early signs of tumor cell death in response to a novel virus-based cancer therapy.

Quelle: Sciencedaily

Targeting the brain’s immune cells may help prevent or treat Alzheimer’s disease

A gene mutation linked to Alzheimer’s disease alters a signaling pathway in certain immune cells of individuals with the disease, according to a new study. The team also found that blocking the pathway — with a drug that’s currently being tested in cancer clinical trials — protects against many features of the condition in a preclinical model. The results could lead to new strategies to block the development of Alzheimer’s disease or slow its progression.

Quelle: Sciencedaily

Discovery of a Stem-like T cell in type 1 diabetes holds potential for improving cancer immunotherapy

As an autoimmune disease, Type 1 diabetes raises important questions about immune cell activity that have broad implications for immunotherapy.

Quelle: Sciencedaily

Biosensor barcodes identify, detail ‘chatting’ among cancer cells

Ever since the first barcode appeared on a pack of chewing gum in 1974, the now-ubiquitous system has enabled manufacturers, retailers and consumers to quickly and effectively identify, characterize, locate and track products and materials. Scientists now demonstrate how they can do the same thing at the molecular level, studying the ways cancer cells ‚talk‘ with one another.

Quelle: Sciencedaily

Successful treatment in mice for severe childhood cancer

In mice with high-risk neuroblastoma, tumors disappeared in response to a new combination treatment with precision medicines, a recent study shows. This is a vital step toward a potentially curative treatment for a form of cancer affecting young children that is currently difficult to treat.

Quelle: Sciencedaily

Which glioblastoma patients will respond to immunotherapy?

Scientists have discovered a new biomarker to identify which patients with brain tumors called glioblastomas — the most common and malignant of primary brain tumors — might benefit from immunotherapy. The treatment could extend survival for an estimated 20% to 30% of patients. Currently, patients with glioblastoma do not receive this life-prolonging treatment because it has not been fully understood which of them could benefit.

Quelle: Sciencedaily

Parallels in human, dog oral tumors could speed new therapies

Recent research compared the genetic expression profiles of a nonlethal canine tumor and the rare, devastating human oral tumor it resembles, laying the groundwork for potential translational medicine down the road.

Quelle: Sciencedaily

How moles change into melanoma

Melanoma researchers published a study that gives a new explanation of what causes moles to change into melanoma. These findings pave the way for more research into how to reduce the risk of melanoma, delay development, and detect melanoma early.

Quelle: Sciencedaily

Chemotherapy may affect muscle cells at lower doses than previously thought

Previous research has found that chemotherapy can trigger muscle loss in people living with cancer, but a new study out of found it may also affect the way the body builds new muscle — and at lower doses than previously known, having potential implications for treatments and rehab programs.

Quelle: Sciencedaily

Strategy to overcome tumors’ resistance to immunotherapy generates promising clinical trial results

Immune checkpoint inhibitors strengthen the immune response against cancer cells, but the medications are ineffective against certain tumors. Results from a new clinical trial indicate that adding radiation may overcome this resistance to immune checkpoint inhibitors.

Quelle: Sciencedaily

New imaging technology may reduce need for skin biopsies

A new ‚virtual histology‘ technology shows promise by analyzing images of suspicious-looking lesions and quickly producing a detailed, microscopic image of the skin, bypassing several standard steps typically used for diagnosis — including skin biopsy, tissue fixation, processing, sectioning and histochemical staining.

Quelle: Sciencedaily

Kinder mit Krebs – geheilt, doch das Herz geschädigt?

Eine von der Herzstiftung geförderte Studie untersucht, ob sich bei jungen Patienten Herzschäden nach einer Krebstherapie früher erkennen lassen.

Quelle: IDW Informationsdienst Wissenschaft

New findings on the link between CRISPR gene-editing and mutated cancer cells

A protein that protects cells from DNA damage, p53, is activated during gene editing using the CRISPR technique. Consequently, cells with mutated p53 have a survival advantage, which can cause cancer. Researchers have found new links between CRISPR, p53 and other cancer genes that could prevent the accumulation of mutated cells without compromising the gene scissors‘ effectiveness.

Quelle: Sciencedaily

Shape-morphing microrobots deliver drugs to cancer cells

Chemotherapy successfully treats many forms of cancer, but the side effects can wreak havoc on the rest of the body. Delivering drugs directly to cancer cells could help reduce these unpleasant symptoms. Now, in a proof-of-concept study, researchers have made fish-shaped microrobots that are guided with magnets to cancer cells, where a pH change triggers them to open their mouths and release their chemotherapy cargo.

Quelle: Sciencedaily

Exercise increases the body’s own ‘cannabis-like‘ substance which reduces chronic inflammation

Exercise increases the body’s own cannabis-like substances, which in turn helps reduce inflammation and could potentially help treat certain conditions such as arthritis, cancer and heart disease.

Quelle: Sciencedaily

Outcomes for hospitalized COVID-19 patients taking immunosuppressive medications similar to non-immunosuppressed patients, study finds

A study of more than 200,000 U.S adults hospitalized with COVID-19 finds that, overall, patients taking immunosuppressive drugs do not face increased risk of being put on a ventilator or death.

Quelle: Sciencedaily

The prostate cancer cell that got away

Researchers have pioneered a new method to track the progression of prostate cancer in mice, from its birth to its spread into other tissues. This approach allows researchers to study the origins of prostate cancer in a more realistic context than traditional methods allow.

Quelle: Sciencedaily

Toward ‚off-the-shelf’ immune cell therapy for cancer

Immunotherapies, which harness the body’s natural defenses to combat disease, have revolutionized the treatment of aggressive and deadly cancers. But often, these therapies — especially those based on immune cells — must be tailored to the individual patient, costing valuable time and pushing their price into the hundreds of thousands of dollars.

Quelle: Sciencedaily

Using T cells to target malignant brain tumors

Doctors and scientists have successfully tested a neoantigen-specific transgenic immune cell therapy for malignant brain tumors for the first time using an experimental model in mice.

Quelle: Sciencedaily

For stem cells, bigger doesn’t mean better

A new study suggests that enlargement of stem cells contributes to age-related decline in function. The researchers found that blood stem cells, which are among the smallest cells in the body, lose their ability to perform their normal function — replenishing the body’s blood cells — as they grow larger. When the cells were restored to their usual size, they behaved normally again.

Quelle: Sciencedaily

Illuminating dark matter in human DNA

Researchers have produced a single-cell chromatin atlas for the human genome. Delineating chromatin regions in cells of different human tissue types would be a major step toward understanding the role of gene regulatory elements (non-coding DNA) in human health or disease.

Quelle: Sciencedaily

Team engineers new way to get medication past blood-brain barrier

A team of researchers has developed a new technique to open the blood-brain barrier temporarily to deliver medication to the brain. Getting medication past the brain’s unique and protective blood vessels, known as the blood-brain barrier, is one of the biggest challenges in treating brain and central nervous system diseases, according to researchers. The technique uses light and nanoparticles to pry open temporarily these barriers — called tight junctions — to allow medication to reach its target.

Quelle: Sciencedaily