‘Gut bugs’ can drive prostate cancer growth and treatment resistance

Common gut bacteria can become ‚hormone factories‘ – fuelling prostate cancer and making it resistant to treatment, a new study shows. Scientists revealed how gut bacteria contribute to the progression of advanced prostate cancers and their resistance to hormone therapy — by providing an alternative source of growth-promoting androgens, or male hormones. The findings, once further validated in the clinic, could provide new opportunities for the treatment of prostate cancer through manipulation of the microbiome.

Quelle: Sciencedaily

Metastatic prostate cancer comes in two forms, which could guide treatment

Scientists have identified two subtypes of metastatic prostate cancer that respond differently to treatment, information that could one day guide physicians in treating patients with the therapies best suited to their disease.

Quelle: Sciencedaily

Studies biased toward genomes of people with European ancestry still predict cancer risk in diverse groups, research finds

Data sets that are biased by having too many genomes from people with European ancestry can still be applied to other ancestry groups to predict their risk of developing breast and prostate cancer, researchers report.

Quelle: Sciencedaily

New blood test improves prostate cancer screening

Researchers recently reported that magnetic resonance imaging (MRI) could reduce overdiagnoses and thereby improve prostate cancer screening. Now, the same research group shows that the addition of a novel blood test, the Stockholm3 test, can reduce the number of MRIs performed by a third while further preventing the detection of minor, low-risk tumors.

Quelle: Sciencedaily

Anti-androgen therapy can fuel spread of bone tumors in advanced prostate cancer

Anti-androgen therapy is commonly used to treat patients with advanced prostate cancer at stages where the disease has spread to the bones. However, new research has found that anti-androgen treatment can actually facilitate prostate cancer cells to adapt and grow in the bone tumor microenvironment model developed by biomedical scientists.

Quelle: Sciencedaily

New insights into androgen’s action could boost battle against prostate cancer

Researchers have unveiled important new insights into how hormones known as androgens act on our cells – and the discovery could boost efforts to develop better treatments for prostate, ovarian and breast cancers.

Quelle: Sciencedaily

Engineering T cells to attack cancer broadly

This study builds on decades of work showing that the protein IL-24 attacks cancer broadly, and is the first to deliver the protein using T cells. This approach is in contrast to CAR-T cells, which are built to recognize proteins on the surface of cancer cells and haven’t been successful against solid tumors. Mice with prostate cancer experienced shrinkage of the original tumor as well as distant metastases following treatment with IL-24 T cells.

Quelle: Sciencedaily

New prostate cancer test could avoid unnecessary biopsies

A urine test could have avoided one third of unnecessary prostate cancer biopsies while failing to detect only a small number of cancers, according to a validation study that included more than 1,500 patients.

Quelle: Sciencedaily

Genomic test helps estimate risk of prostate cancer metastasis, death

A commercially available genomic test may help oncologists better determine which patients with recurrent prostate cancer may benefit from hormone therapy, according to new research.

Quelle: Sciencedaily

An unexpected, and novel, target for prostate cancer: Our biological clock

Researchers find that CRY-1, a regulator of circadian rhythms, promotes tumor progression by altering DNA repair.

Quelle: Sciencedaily

Higher coffee intake may be linked to lower prostate cancer risk

Drinking several cups of coffee every day may be linked to a lower risk of developing prostate cancer, suggests a pooled data analysis of the available evidence.

Quelle: Sciencedaily

MRI frequently underestimates tumor size in prostate cancer

Improving imaging processes will lead to more successful treatments and help reduce morbidity in men with the disease.

Quelle: Sciencedaily

Mediterranean diet may decrease risk of prostate cancer progression

In a study to examine a Mediterranean diet in relation to prostate cancer progression in men on active surveillance, researchers found that men with localized prostate cancer who reported a baseline dietary pattern that more closely follows the key principles of a Mediterranean-style diet fared better over the course of their disease.

Quelle: Sciencedaily

Inflammation from ADT may cause fatigue in prostate cancer patients

Researchers are investigating whether inflammation in the body, a side effect of ADT, contributes to these symptoms in prostate cancer patients. They pinpoint a specific inflammation marker that is associated with increased fatigue in this group of patients.

Quelle: Sciencedaily

Prostate cancer regulator plays role in COVID-19, providing a promising treatment lead

Clinical trials underway are testing whether drugs that target the androgen receptor — successful in controlling prostate cancer — could also work against the coronavirus.

Quelle: Sciencedaily

Gene signature predicts whether localized prostate cancer is likely to spread

Researchers have identified a gene signature in localized prostate cancer that predicts the cancer’s odds of spreading and its response to a common treatment for advanced disease.

Quelle: Sciencedaily

Toward a new staging system for prostate cancer, and why it matters

The development and validation of a staging system for non-metastatic prostate cancer could help doctors and patients assess treatment options, as well as improve clinical trials.

Quelle: Sciencedaily

Cerenkov luminescence imaging identifies surgical margin status in radical prostatectomy

A new intraoperative imaging technique, Cerenkov luminescence imaging (CLI), can accurately assess surgical margins during radical prostatectomy, according to a first-in-human research. The feasibility study showed that 68Ga-PSMA CLI can image the entire excised prostate specimen’s surface to detect prostate cancer tissue at the resection margin.

Quelle: Sciencedaily

Advanced prostate cancer has an unexpected weakness that can be targeted by drugs

Researchers reported that the SUCLA2 gene is frequently involved in the deletion of the tumor suppressor gene RB1 in advanced prostate cancer. RB1 deletion makes cells resistant to hormone therapy but SUCLA2 deletion induces a metabolic weakness. The study showed that thymoquinone selectively killed SUCLA2-deficient prostate cancer cells in vitro and in vivo. The findings highlight a vulnerability of advanced prostate cancer cells that can be targeted by drugs.

Quelle: Sciencedaily

Novel insights of how prostate cancer causes secondary tumors

An increased awareness on a molecular level of what mechanisms prostate cancer cells use to become mobile and start spreading may in the long run provide new opportunities for treatment of aggressive prostate cancer. This according to a new study by researchers at Umeå University, Sweden, in collaboration with researchers in Uppsala and Tokyo.

Quelle: Sciencedaily

Sugars could be the key to an earlier, more accurate test for prostate cancer

A new type of test that uses complex sugars to detect prostate cancer earlier and with greater accuracy.

Quelle: Sciencedaily

Study examines prostate cancer treatment decisions

A five-year follow-up study of more than 2,000 US men who received prostate cancer treatment is creating a road map for future patients regarding long-term bowel, bladder and sexual function in order to clarify expectations and enable men to make informed choices about care.

Quelle: Sciencedaily

Artificial intelligence identifies previously unknown features associated with cancer recurrence

Artificial intelligence (AI) technology has successfully found features in pathology images from human cancer patients, without annotation, that could be understood by human doctors. Further, the AI identified features relevant to cancer prognosis that were not previously noted by pathologists, leading to a higher accuracy of prostate cancer recurrence compared to pathologist-based diagnosis.

Quelle: Sciencedaily

Reducing the side-effects of prostate hormone therapy with exercise

A prescription of short-term exercise for patients with advanced prostate cancer could help to reduce the side-effects of hormone therapy, according to new research. The trial aimed to reduce the adverse side-effects of hormone therapy such as weight gain and an increased risk of heart problems. The results show that a three month programme of aerobic and resistance training intervention prevented adverse changes in cardiopulmonary fitness and fatigue

Quelle: Sciencedaily

New strategies against bone metastases from prostate cancer

A study suggests a new approach, or, possibly two new approaches against prostate cancer bone metastases: While targeted therapies and anti-cancer immunotherapies have not been especially successful against primary prostate cancers, the study suggests that both these approaches may be effective against the bone metastases that grow from primary prostate cancers, and, in fact, the type of bone metastasis may dictate which targeted therapies and immunotherapies work best.

Quelle: Sciencedaily