Targeting cancer at the nanoscale

Researchers fabricate gold nanoparticles with a rapidly decaying radioisotope that can be internalized by cancer cells. Because the radiation remains strongly localized, high doses can be administered without concern for side effects. This research may lead to safer and more effective treatments for many types of cancer.

Quelle: Sciencedaily

Starting mammography at age 40 would reduce disparities in deaths for Black women

If Black women begin mammography screening every other year starting at age 40, breast cancer deaths could be reduced by 57 percent compared to starting screening 10 years later according to recent analyses.

Quelle: Sciencedaily

New active agent against parasites

Researchers have identified a chemical compound that may be suitable as an active agent against several different unicellular parasites. Among these are the pathogens that cause malaria and toxoplasmosis. The point of attack for this promising substance is the protein tubulin: It helps cells divide and therefore is essential for the multiplication of the parasites.

Quelle: Sciencedaily

The human immune system is an early riser

Circadian clocks, which regulate most of the physiological processes of living beings over a rhythm of about 24 hours, are one of the most fundamental biological mechanisms. By deciphering the cell migration mechanisms underlying the immune response, scientists have shown that the activation of the immune system is modulated according to the time of day. Indeed, the migration of immune cells from the skin to the lymph nodes oscillates over a 24-hours period. Immune function is highest in the resting phase, just before activity resumes — in the afternoon for mice, which are nocturnal animals, and early morning for humans. These results suggest that the time of day should possibly be taken into account when administering vaccines or immunotherapies against cancer, in order to increase their effectiveness.

Quelle: Sciencedaily

Neuroinflammation protein linked to worse survival in men with glioblastoma

Scientists have discovered a new link that could bring the scientific and medical community closer to understanding why glioblastoma, the most common malignant brain tumor, is deadlier in males than females.

Quelle: Sciencedaily

Aging breast tissue could set the stage for invasive breast cancer

A new study examines how the extracellular matrix (ECM) — an underlying network of molecules and proteins that provide the structure for tissue growth — can trigger invasive cancer-related genes.

Quelle: Sciencedaily

Molecular atlas of small cell lung cancer reveals unusual cell type that could explain why it’s so aggressive

Stem-like cells that make up only a tiny fraction of the total cells in a lung tumor could be the key to stopping the disease’s deadly spread, say researchers.

Quelle: Sciencedaily

Mito warriors: Scientists discover how T cell assassins reload their weapons to kill and kill again

Researchers have discovered how T cells — an important component of our immune system — are able keep on killing as they hunt down and kill cancer cells, repeatedly reloading their toxic weapons.

Quelle: Sciencedaily

Data continues to show that American’s need at least 5 hours per week of physical activity to prevent some cancers

A new report finds more than 46,000 cancer cases annually in the United States could be prevented if Americans met the 5 hours per week of moderate-intensity recommended physical activity guidelines.

Quelle: Sciencedaily

Solving mystery of rare cancers directly caused by HIV

For nearly a decade, scientists have known that HIV integrates itself into genes in cells that have the potential to cause cancer. And when this happens in animals with other retroviruses, those animals often develop cancer. But, perplexingly and fortunately, that isn’t regularly happening in people living with HIV. A new study reveals why doctors aren’t seeing high rates of T cell lymphomas — or cancers of the immune system — in patients with HIV.

Quelle: Sciencedaily

Fluorescent spray lights up tumors for easy detection during surgery

The prognosis for a cancer patient who undergoes surgery is better if the surgeon removes all of the tumor, but it can be hard to tell where a tumor ends and healthy tissue begins. Now, scientists report that they have developed a fluorescent spray that specifically lights up cancerous tissue so it can be identified readily and removed during surgery.

Quelle: Sciencedaily

Scientists discover a highly potent antibody against SARS-CoV-2

Scientists have discovered a highly potent monoclonal antibody that targets the SARS-CoV-2 spike protein and is effective at neutralizing all variants of concern identified to date, including the delta variant.

Quelle: Sciencedaily

Researcher discovers key gene responsible for cancer drug resistance

A researcher has discovered an enzyme that plays a key role in the ability of cancer cells to resist drug treatment.

Quelle: Sciencedaily

Mushroom consumption may lower risk of depression

Mushrooms have been making headlines due to their many health advantages. Not only do they lower one’s risk of cancer and premature death, but new research also reveals that these super-foods may benefit a person’s mental health.

Quelle: Sciencedaily

Aadvance in rapid cancer detection and monitoring

An engineer is reporting fast screening of the surface proteins of exosomes for cancer diagnostics and biomarker discovery.

Quelle: Sciencedaily

Antiviral compound blocks SARS-CoV-2 from entering cells

Scientists have developed a chemical compound that interferes with a key feature of many viruses that allows the viruses to invade human cells. The compound, called MM3122, was studied in cells and mice and holds promise as a new way to prevent infection or reduce the severity of COVID-19 if given early in the course of an infection, according to the researchers.

Quelle: Sciencedaily

Researchers find cervical cancer screening is overused – and underused as well

New research finds many women are screened too often for cervical cancer, leading to unnecessary procedures that may carry their own harms, while some women are not getting tested often enough, putting them at higher risk for poor outcomes.

Quelle: Sciencedaily

Break through the tumor’s protective shield

The immune system protects the body from cancer. To protect healthy body cells from its own immune system, they have developed a protective shield: the protein CD47 is a so called ‚don’t eat me‘ signal, which tells the immune cells to stand back. Tumor cells exploit this CD47-based protection strategy for evading the immune system, by increasing presentation of CD47 on their cell surface. A team has now developed a therapy concept for programming the tumor cells to produce on their own a CD47-blocking and immune-activation fusion protein. This therapy approach could stop tumor growth.

Quelle: Sciencedaily

‘Gut bugs’ can drive prostate cancer growth and treatment resistance

Common gut bacteria can become ‚hormone factories‘ – fuelling prostate cancer and making it resistant to treatment, a new study shows. Scientists revealed how gut bacteria contribute to the progression of advanced prostate cancers and their resistance to hormone therapy — by providing an alternative source of growth-promoting androgens, or male hormones. The findings, once further validated in the clinic, could provide new opportunities for the treatment of prostate cancer through manipulation of the microbiome.

Quelle: Sciencedaily

Researchers identify new drug target for blood cancer, potentially solid tumors

Researchers have shown for the first time how mutations affecting a cellular process called RNA splicing alter cells to develop myelodysplastic syndrome (MDS) and other hematologic malignancies and solid tumors.

Quelle: Sciencedaily

Small molecule may prevent metastasis in colorectal cancer

The compound works by hindering a key pathway that cancer cells rely upon to hoard energy, and is already undergoing clinical trials.

Quelle: Sciencedaily

Common diabetes drug promising against rare childhood brain tumor in laboratory studies

Metformin, a drug commonly prescribed against diabetes, holds promise against a rare type of childhood brain tumor in laboratory studies, an international team of researchers.

Quelle: Sciencedaily

Protecting the ozone layer is delivering vast health benefits

An international agreement to protect the ozone layer is expected to prevent 443 million cases of skin cancer and 63 million cataract cases for people born in the United States through the end of this century, according to new research. The research team developed a computer modeling approach that revealed the effect of the Montreal Protocol and subsequent amendments on stratospheric ozone, the associated reductions in ultraviolet radiation, and the resulting health benefits.

Quelle: Sciencedaily

Cancer costs US more than $156 billion annually, with drugs a leading expense

Care for the 15 most prevalent types of cancer in the U.S. cost approximately $156.2 billion in 2018, according to a team researchers. The team also found that medication was the biggest expense and that medication expense for breast, lung, lymphoma and colorectal cancers incurred the most costs.

Quelle: Sciencedaily

Weighing cancer cells to personalize drug choices

Researchers have developed a new way to determine whether individual patients will respond to a specific cancer drug or not. This kind of test could help doctors to choose alternative therapies for patients who don’t respond to the therapies normally used to treat their cancer.

Quelle: Sciencedaily